![]() Conditioning, PBHSC infusion, and initial recovery usually are performed during an approximately 1-month hospitalization in a specialized transplant unit. Mobilization typically is performed as an outpatient. The principal purpose of the transplant is to shorten the aplastic phase after conditioning and lessen the resultant adverse effects, though some data suggest that it might contribute to immune reconstitution with more normal regulatory function and self-tolerance. At Cleveland Clinic, we currently utilize BEAM (carmustine, etoposide, cytarabine, melphalan) plus anti-thymocyte globulin, an intermediate intensity conditioning regimen, for AHSCT for MS. Conversely, the highest intensity myeloablative regimens may have more potent or durable efficacy, but have greater risk. ![]() 1 The lower intensity non-myeloablative regimens are better tolerated but may have somewhat less potent or durable efficacy. The optimal intensity conditioning regimen currently is uncertain. Conditioning regimens all are immunoablative but range in intensity from low-intensity non-myeloablative regimens to high-intensity potently myeloablative regimens. The ablative conditioning eliminates the existing immune cells and is the component of the protocol that represents MS disease therapy per se. Conditioning with high-dose chemotherapy.At Cleveland Clinic, we do not utilize CD34 selection for AHSCT for MS. Mobilization of autologous peripheral blood hematopoietic (blood-forming) stem cells (PBHSCs), typically by treatment with cyclophosphamide and granulocyte colony stimulating factor, harvest (collection by leukapheresis) and cryopreservation sometimes with selection of CD34+ cells.Q: What does AHSCT entail?Ī: AHSCT is a multi-step procedure, which includes: This document addresses AHSCT and MSC transplantation separately. Repair-promoting strategies – typified by mesenchymal stem cell (MSC) transplantation.Anti-inflammatory strategies – typified by autologous hematopoietic stem cell transplantation (AHSCT).Two general stem-cell-based therapeutic strategies have been considered in MS: 1 Induced pluripotent stem cells – stem cells generated from adult somatic cells through molecular reprogramming.Adult stem cells – various types of stem cells present in virtually all body tissues in the adult, including neural stem cells and oligodendrocyte progenitor cells in the adult central nervous system.Embryonic stem cells – the prototypic stem cells present in the inner cell mass of the blastocyst that give rise to all the cell types in the developing embryo.There are several general categories of stem cells, including: Q: What are the types of stem cell therapy?Ī: Stem cells are primitive cells that are capable of self-renewal (i.e., to divide to replenish their population) are pluripotent (i.e., able to differentiate into different mature cells) and are able to create, maintain, or repair tissues.
0 Comments
Leave a Reply. |